Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: PD-1 expression on peripheral CD8+ TEM/TEMRA subsets closely correlated with HCV viral load in chronic hepatitis C patients | Shen et al. Virology Journal 2010 7 310 http content 7 1 310 VIROLOGY JOURNAL RESEARCH Open Access PD-1 expression on peripheral CD8 TEM TEMRA subsets closely correlated with HCV viral load in chronic hepatitis C patients 1t 1t 11 2 1 1 Tao Shen Jiajia Zheng Chunhui Xu Jia Liu Weidong Zhang Fengmin Lu Hui Zhuang Abstract Background Tight correlation between host circulating CD8 T cell-mediated immune response and control of viral replication is classical characteristic of long-term HCV infection. CD8 T cell maturation activation markers are expected to be associated with viral replication and disease progression in chronic HCV infection. The aim of the present study was to explore novel markers on CD8 T cells with ability to evaluate HCV viral replication and disease progression. Methods PBMCs were isolated from 37 chronic HCV-infected patients and 17 healthy controls. Distributed pattern of CD8 T cells subsets and expression of PD-1 CD38 HLA-DR and CD127 were analyzed by flow cytometry. The correlation between expression of surface markers and HCV viral load or ALT was studied. Results Declined naive and increased TEMRA CD8 T subsets were found in HCV-infected individuals compared with healthy controls. Percentage and MFI of PD-1 CD38 and HLA-DR on all CD8 T cell subsets were higher in HCV-infected patients than healthy controls. In contrast CD127 expression on CD8 TCM showed an opposite trend as PD-1 CD38 and HLA-DR did. In chronic HCV infection MFI of PD-1 on CD8 TEM p and TEMRA p was positively correlated with HCV viral load while HLA-DR expression on non-naive CD8 T cell subsets p was negatively correlated with HCV viral load. Conclusion PD-1 level on peripheral CD8 TEM TEMRA was highly correlated with HCV viral load in chronic HCV-infected patients which made PD-1 a novel indicator to evaluate HCV replication and disease progression in chronic hepatitis C patients. Background Hepatitis C virus HCV infection was prevalent .
