Phân hủy sinh học liên kết lỏng lẻo với các thành phần có thể được chia nhỏ theo tính chất hoặc thông qua các cơ chế thủy phân mà không cần sự giúp đỡ của các enzyme và / hoặc cơ chế enzyme. Các điều khoản khác như hấp thụ, erodible, và resorbable cũng đã được sử dụng trong các tài liệu để chỉ phân hủy sinh học. | Chih-Chang Chu Cornell University 6 Biodegradable Polymeric Biomaterials An Updated Overview Introduction. 6-1 Glycolide Lactide Based Biodegradable Linear Aliphatic Polyesters. 6-3 Glycolide Based Biodegradable Homopolymers Polyesters Glycolide-Based Biodegradable Copolyesters Having Aliphatic Polyester Based Co-Monomers Glycolide-Based Biodegradable Copolyesters with Non-Aliphatic Polyester-Based Co-Monomers Glycolide-Derived Biodegradable Polymers Having Ether Linkage Lactide Biodegradable Homopolymers and Copolymers Non-Glycolide Lactide Based Linear Aliphatic Polyesters. 6-9 Non-Aliphatic Polyesters Type Biodegradable Polymers. 6-9 Aliphatic and Aromatic Polycarbonates Poly alkylene oxalates and Copolymers Biodegradation Properties of Synthetic Biodegradable Polymers. 6-10 Theoretical Modeling of Degradation Properties The Role of Free Radicals in Degradation Properties The Role of Linear Aliphatic Biodegradable Polyesters in Tissue Engineering and Regeneration. 6-14 Defining Terms. 6-16 References . 6-16 Further Information. 6-21 Introduction The term biodegradation is loosely associated with materials that could be broken down by nature either through hydrolytic mechanisms without the help of enzymes and or enzymatic mechanism. Other terms like absorbable erodible and resorbable have also been used in the literature to indicate biodegradation. 6-1 2007 by Taylor Francis Group LLC 6-2 Biomaterials TABLE Properties of Commercially Important Synthetic Absorbable Polymers Fiber Polymer Crystallinity Tm C Tg C Tdec C Strength MPa Modulus GPa Elongation PGA High 230 36 260 890 30 PLLA High 170 56 240 900 25 PLA None 57 Polyglactin910a Highc 200 40 250 850 24 Polydioxanone High 106 20 190 490 35 Polyglyconateb Highc 213 20 260 550 45 Poliglecaprone25d 220 -36 15 91 100e 113 000e 39 a Glycolide per lactide 9 1. b Glycolide per trimethylene carbonate 9 1. c Depending on the copolymer composition. d 2 0 size Monocryl
