Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Chitosan can stop or postpone the death of the suckling mice challenged with foot-and-mouth disease virus | Li Virology Journal 2010 7 125 http content 7 1 125 VIROLOGY JOURNAL SHORT REPORT Open Access Chitosan can stop or postpone the death of the suckling mice challenged with foot-and-mouth disease virus Dong Li Abstract In the study a method called hardening in liquid phase for preparing chitosan granules with glutaraldehyde as crosslinker and Tween 80 as surfactant and paraffin liquid as dispersant was established. The chitosan granules were light yellow and insoluble in water or oil but they swelled in acid solution and narrowed in neutral or alkaline solution. Furthermore some of characteristics of the chitosan granules were revealed. a Stability Their shapes were stable at pH and pH and -30 C 120 C. The shelf life is at least one year in vitro at room temperature. b Safety Some experiments of their lethal effect to suckling mice and pathogenicity to mature mice proved the chitosan granules were harmless. c Antiviral activity Some suckling mice injected with chitosan granules were still alive or delayed death compared with control group when they challenged with foot-and-mouth disease virus FMDV . Such anti-FMDV capacity could maintain 1 week and was the strongest on the third day. Findings Chitosan deacetylated chitin is derived from chitin the component of the cell walls of fungi the shells of insects and especially crustaceans. Thus it is can be serviced relatively inexpensively from widely available materials which is the second most abundant polysaccharide in nature. Chitosan is the commonly used name for poly- 1-4 -p-D-glucosamine 3 . As we know the available antibody will be induced in 1 week after the antigens or vaccines enter animal s bodies. The pathogens can invade bodies easily in the empty period without specific immune defense. Some immunopotentiators can remedy such limitation. Chitosan is a good example. In this report a method called hardening in liquid phase to prepare chitosan granules were established and some of .
