Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Prevalence of human papillomavirus infection and genotype distribution among high-risk Korean women for prospecting the strategy of vaccine development | Rhee et al. Virology Journal 2010 7 201 http content 7 1 201 VIROLOGY JOURNAL SHORT REPORT Open Access Prevalence of human papillomavirus infection and genotype distribution among high-risk Korean women for prospecting the strategy of vaccine development 12 2 3 3 4 Jee Eun Rhee Mi Yeong Shin Choong Mo Kim Hye Young Kee Jae Keun Chung Sang-Kee Min Seong-Joon Kim4 Dai-Ho Jang 1 Sung Soon Kim1 Byeong-Sun Choi1 Abstract We investigated the prevalence of human papillomavirus HPV infection and the distribution of high-risk HPV genotypes among 2 308 high-risk Korean women to predict how much the current prophylactic HPV vaccines might affect the prevention of cervical cancer in Korea. HPV DNA was detected in 939 women but only one-third of women were positive for HPV-16 and or HPV-18 the genotypes used for developing the HPV vaccines. Thus the development of area-specific HPV vaccines based on dominant HPV genotypes in our country is needed for preventing HPV infection and the development of premalignant lesions in the cervix of Korean women. Findings Infection with certain types of human papillomavirus HPV is recognized as a causal and necessary factor for developing cervical cancer 1 2 which is the fourth of the most common cancer in South Korean women 3 . More than 140 different HPV genotypes have been characterized and approximately 50 of these genotypes are known to infect the genital tract and be oncogenic or high-risk HR types HPV-16 -18 -31 -33 -35 -39 -45 -51 -52 -56 -58 -59 -66 and -68 . HR genotypes are significantly associated with progression to invasive cervical cancer 2 4 . Therefore assessment of the HPV genotypic spectrum among sexually active women is important for predicting public health problems such as the risks of developing cervical intraepithelial neoplasia and cervical cancer 5 6 . HPV-16 the most common HR type is detected in 50 - 60 of high-grade squamous intraepithelial lesions and invasive cervical cancers and HPV-18 is
