Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Bovine viral diarrhea virus NS4B protein is an integral membrane protein associated with Golgi markers and rearranged host membranes | Virology Journal BioMed Central Open Access Bovine viral diarrhea virus NS4B protein is an integral membrane protein associated with Golgi markers and rearranged host membranes Erica Weiskircher1 3 Jason Aligo1 Gang Ning2 and Kouacou V Konan 1 Address Department of Biochemistry and Molecular Biology The Pennsylvania State University University Park PA 16802 USA 2The Huck Institutes of the Life Sciences The Pennsylvania State University University Park PA 16802 USA and 3Absorption Systems LP Exton PA 19341 USA Email Erica Weiskircher - EWeiskircher@ Jason Aligo - jaa237@ Gang Ning - gxn7@ Kouacou V Konan - kvk10@ Corresponding author Published 3 November 2009 Received 31 August 2009 Accepted 3 November 2009 Virology Journal 2009 6 185 doi I743-422X-6-I85 This article is available from http content 6 1 185 2009 Weiskircher et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Very little is known about BVDV NS4B a protein of approximately 38 kDa. However a missense mutation in NS4B has been implicated in changing BVDV from a cytopathic to noncytopathic virus suggesting that NS4B might play a role in BVDV pathogenesis. Though this is one possible function it is also likely that NS4B plays a role in BVDV genome replication. For example BVDV NS4B interacts with NS3 and NS5A implying that NS4B is part of a complex which contains BVDV replicase proteins. Other possible BVDV NS4B functions can be inferred by analogy to hepatitis C virus HCV NS4B protein. For instance HCV NS4B remodels host membranes to form the so-called membranous web the site for HCV genome replication. Finally HCV NS4B is membrane-associated implying that HCV NS4B may anchor the .
