Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Cellular receptor binding and entry of human papillomavirus | Letian and Tianyu Virology Journal 2010 7 2 http content 7 1 2 VIROLOGY JOURNAL REVIEW Open Access Cellular receptor binding and entry of human papillomavirus Tan Letian1 Zhang Tianyu2 Abstract Human papillomaviruses HPVs recognized as the etiological agents for the skin plantar genital and laryngopharyngeal wart have been previously in numerous studies demonstrated to present a close link between HPV infection and certain human cancers some putative candidates of HPV cell receptor and possible pathways of cell entry proposed. This review was to highlight the investigations and remaining questions regarding the binding and entry process. Introduction As the well-recognized etiological agents for the skin plantar genital and laryngopharyngeal wart human papillomaviruses HPVs have been proven of a close link between HPV infection and certain human cancers. And considerable effort has been made in developing a prophylactic vaccine and devising effective treatments of HPV-induced lesions. It has been found that the early events of HPV infection such as cellular receptor binding and entry into susceptible cells could provide potential targets of inhibiting the spread of a HPV infection. HPVs are nonenveloped double-strained DNA viruses about 55 nm in diameter with an approximately 8-kb genome in the nucleohistone core and their capsids are composed of two virally encoded proteins L1 and L2 with L1 the major capsid protein mainly responsible for initial binding to the cell surface and arranged in 72 pentamers which associate with T 7 icosahedral symmetry 1 . Even in the absence of other viral proteins L1 self-assembles into empty capsid or virus-like particles VLPs 2 L2 is incorporated into VLPs when coexpressed with L1 . L1 L2 VLPs in insect or mammalian cells 1 . It is well known that difficulties in generating HPVs in vitro hinder the study on the pathway of infection. Recent research predominantly utilized synthetic HPV particles such as VLPs .
