Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Species and age related differences in the type and distribution of influenza virus receptors in different tissues of chickens, ducks and turkeys | Pillai and Lee Virology Journal 2010 7 5 http content 7 1 5 VIROLOGY JOURNAL RESEARCH Open Access Species and age related differences in the type and distribution of influenza virus receptors in different tissues of chickens ducks and turkeys Smitha PS Pillai1 2 Chang W Lee1 2 Abstract We undertook one of the most detailed studies on the distribution of a2 3 sialic acid SA -galactose gal avian type and a2 6SA-gal human type receptors on different tissues of chickens ducks and turkeys of varying age groups. On the tracheal epithelium all 3 bird species expressed strong positive staining 80-90 for a2 3SA-gal receptors in the 3 different age groups. In addition a lesser amount of a2 6SA-gal receptors 30-90 were observed with slight differences in distribution with age and species. The epithelium of the small and large intestine of turkeys and ducks showed negligible staining for a2 6SA-gal receptors whereas the large intestine consistently showed 40-70 positive staining for a2 3SA-gal receptors. In contrast a greater amount of staining for a2 3SA-gal 50-80 and a2 6SA-gal 20-50 receptors were observed along the epithelium of small and large intestine of chickens. Kidney and esophagus sections from the 3 bird species also expressed both avian and human type receptors. In other tissues examined brain breast muscles bursa spleen cecal tonsils and oviduct human type receptors were absent. Though different viral and receptor components may play roles in successful viral replication and transmission understanding the receptor types and distribution in different tissues of domestic birds might be good initial tool to understand host factors that promote successful influenza viral infection. Introduction Wild aquatic birds are considered to be the natural reservoir of influenza viruses. They have been implicated as the source of influenza viruses for all other species of birds and mammals 1 2 . In wild aquatic birds influenza viruses are believed to have .
