Báo cáo khoa học:" Conserved peptides within the E2 region of Hepatitis C virus induce humoral and cellular responses in goats"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Conserved peptides within the E2 region of Hepatitis C virus induce humoral and cellular responses in goats | BioMed Central Virology Journal Research Conserved peptides within the E2 region of Hepatitis C virus induce humoral and cellular responses in goats Mostafa K El-Awady 1 Ashraf A Tabll1 Yasmine S El-Abd1 Hassan Yousif1 Mohsen Hegab1 Mohamed Reda1 Reem El Shenawy1 Rehab I Moustafa1 Nabila Degheidy2 and Noha G Bader El Din1 Address Department of Biomedical Technology National Research Center Giza Egypt and 2Parasitology and Animal Diseases Department National Research Center Giza Egypt Email Mostafa K El-Awady - mkawady@ Ashraf A Tabll - Ashraftabll@ Yasmine S El-Abd - mkawady@ Hassan Yousif - mkawady@ Mohsen Hegab - mkawady@ Mohamed Reda - mkawady@ Reem El Shenawy - mkawady@ Rehab I Moustafa - mkawady@ Nabila Degheidy - mkawady@ Noha G Bader El Din - mkawady@ Corresponding author Open Access Published 27 May 2009 Received 4 March 2009 Accepted 27 May 2009 Virology journal 2009 6 66 doi 1743-422X-6-66 This article is available from http content 6 1 66 2009 El-Awady et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The reason s why human antibodies raised against hepatitis C virus HCV E2 epitopes do not offer protection against multiple viral infections may be related to either genetic variations among viral strains particularly within the hypervariable region-1 HVR-I low titers of anti E2 antibodies or interference of non neutralizing antibodies with the function of neutralizing antibodies. This study was designed to assess the immunogenic properties of genetically conserved peptides derived from the C-terminal region of HVR-1 .

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