Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Evolution of the M gene of the influenza A virus in different host species: large-scale sequence analysis | BioMed Central Virology Journal Research Evolution of the M gene of the influenza A virus in different host species large-scale sequence analysis Yuki Furuse Akira Suzuki Taro Kamigaki and Hitoshi Oshitani Open Access Address Department of Virology Tohoku University Graduate School of Medicine 2-1 Seiryou-machi Aoba-ku Sendai Japan Email Yuki Furuse - furusey@ Akira Suzuki - suzukia@ Taro Kamigaki - kamigakit@ Hitoshi Oshitani - oshitanih@ Corresponding author Published 29 May 2009 Received 15 April 2009 Accepted 29 May 2009 Virology journal 2009 6 67 doi 1743-422X-6-67 This article is available from http content 6 1 67 2009 Furuse et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Influenza A virus infects not only humans but also other species including avian and swine. If a novel influenza A subtype acquires the ability to spread between humans efficiently it could cause the next pandemic. Therefore it is necessary to understand the evolutionary processes of influenza A viruses in various hosts in order to gain better knowledge about the emergence of pandemic virus. The virus has segmented RNA genome and 7th segment M gene encodes 2 proteins. M1 is a matrix protein and M2 is a membrane protein. The M gene may be involved in determining host tropism. Besides novel vaccines targeting M1 or M2 protein to confer cross subtype protection have been under development. We conducted the present study to investigate the evolution of the M gene by analyzing its sequence in different species. Results .
