Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: In vitro dynamics of HIV-1 BF intersubtype recombinants genomic regions involved in the regulation of gene expression | Virology Journal BioMed Central Research In vitro dynamics of HIV-1 BF intersubtype recombinants genomic regions involved in the regulation of gene expression Mauricio G Carobene t Christian Rodríguez Rodríguesh Cristian A De Candia Gabriela Turk and Horacio Salomón Open Access Address National Reference Center for AIDS Department of Microbiology School of Medicine University of Buenos Aires Buenos Aires Argentina Email Mauricio G Carobene - mcarobe@ Christian Rodríguez Rodrigues - crodriguez@ Cristian A De Candia - cristiandecandia@ Gabriela Turk - gturk@ Horacio Salomon - hsalomon@ Corresponding author tEqual contributors Published 16 July 2009 Received 14 May 2009 Virology Journal 2009 6 107 doi 1743-422X-6-107 Accepted 16 July 2009 This article is available from http content 6 1 107 2009 Carobene et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract HIV-1 intersubtype recombination is a very common phenomenon that has been shown to frequently affect different viral genomic regions. Vpr and Tat are viral proteins known to interact with viral promoter LTR during the replication cycle. This interaction is mainly involved in the regulation of viral gene expression so any structural changes in the LTR and or these regulatory proteins may have an important impact on viral replication and spread. It has been reported that these genetic structures underwent recombination in BF variants widely spread in South America. To gain more insight of the consequences of the BF intersubtype recombination phenomenon on these different but functionally related genomic regions we designed and performed and in vitro study that allowed the detection and .
