Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Central nervous system Toll-like receptor expression in response to Theiler's murine encephalomyelitis virus-induced demyelination disease in resistant and susceptible mouse strains | Virology Journal BioMed Central Research Central nervous system Toll-like receptor expression in response to Theiler s murine encephalomyelitis virus-induced demyelination disease in resistant and susceptible mouse strains Nicolas P Turrin Open Access Address Molecular Endocrinology Oncology Research Centre CHUQ 2705 Laurier Blvd. Quebec City Qc. G1V 4G2 Canada Email Nicolas P Turrin - Published 18 December 2008 Received 24 November 2008 Accepted 18 December 2008 Virology Journal 2008 5 154 doi l743-422X-5-l54 This article is available from http content 5 l l54 2008 Turrin licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In immunopathological diseases such as multiple sclerosis MS genetic and environmental factors that contribute to the initiation and progression of the disease are often discussed. The Theiler murine encephalomyelitis virus-induced demyelination disease TMEV-IDD model used to study MS reflects this genetically susceptible mice infected intra-cerebrally with TMEV develop a chronic demyelination disease. TMEV-IDD can be induced in resistant mouse strains by inducing innate immunity with lipopolysaccharide LPS . Interestingly Toll-like receptor 4 TLR4 is the cognate receptor for LPS and its activation can induces up-regulation of other TLRs such as TLR7 the receptor for TMEV and 9 known to be involved in autoimmunity. Up-regulation of TLRs could be involved in precipitating an autoimmune susceptible state. Consequently we looked at TLR expression in the susceptible SJL J and resistant C57BL 6 strains of mice infected with TMEV. The resistant mice were induced to develop TMEV-IDD by two LPS injections following TMEV infection. Results
