ung thư dạ dày và nhiễm trùng H. pylori đã được khẳng định hơn nữa trong nghiên cứu trên động vật bằng cách sử dụng chuột nhảy Mông Cổ. [27] Trong một nghiên cứu thuần tập tương lai của bệnh nhân Nhật Bản, ung thư dạ dày đã được chứng minh là phát triển 2,9% của 1246 bệnh nhân người lớn bị nhiễm H. pylori. | 300 Hien Q. Huynh Figure 1. Schematic representation of gastric pathology and disease outcome. Adapted from 19 with kind permission of the Massachusetts Medical Society gastric cancer and H. pylori infection has been confirmed further in animal studies using the Mongolian gerbil 27 . In a prospective cohort study of Japanese patients gastric cancer was shown to develop in of 1246 adult patients infected with H. pylori. Mean follow-up was years. No gastric cancer was found in those not infected or in a subgroup of patients who received eradication therapy for H. pylori 28 . However in another prospective randomized placebo-controlled population-based primary study of 1630 healthy Chinese patients carriers of H. pylori infection in a region of China with a high prevalence of gastric cancer 817 received eradication therapy and 813 a placebo. No difference was found in terms of the incidence of gastric cancer development between the two groups over a period of years. In a subgroup analysis of patients without precancerous lesions such as atrophic gastritis and intestinal metaplasia eradication seemed to decrease the development of gastric cancer 29 . A recent trial suggests that eradication of H. pylori may reduce the incidence of precancerous lesions Helicobacter pylori infection in children 301 30 . Eradication of H. pylori in the older individuals with precancerous lesions appeared not to be effective in preventing gastric cancer. Since these precancerous lesions are rarely seen in children 31 perhaps eradication should take place in childhood to prevent the development of these pre-cancerous lesions later in life. Currently the effect of H. pylori eradication on the incidence of gastric cancer is unknown and conclusive trials will take many years. Most experts favor eradication in first-degree relatives of gastric cancer patients 32-34 . Mucosal associated lymphoid tissue MALT lymphoma is rare in those infected with H. pylori with a lifetime risk of .
