Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài :Tremorgenesis: a new conceptual scheme using reciprocally innervated circuit of neurons | Journal of Translational Medicine BioMed Central Open Access Editorial Tremorgenesis a new conceptual scheme using reciprocally innervated circuit of neurons Mario Manto Address FNRS ULB Erasme 808 Route de Lennik 1070 Bruxelles Belgium Email Mario Manto - mmanto@ Published 26 November 2008 Received 24 November 2008 Jrm Accepted 26 November 2008 Journal of Translational Medicine 2008 6 71 doi 1479-5876-6-71 This article is available from http content 6 1 71 2008 Manto licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Neural circuits controlling fast movements are inherently unsteady as a result of their reciprocal innervation. This instability is enhanced by increased membrane excitability. Recent studies indicate that the loss of external inhibition is an important factor in the pathogenesis of several tremor disorders such as essential tremor cerebellar kinetic tremor or parkinsonian tremor. Shaikh and colleagues propose a new conceptual scheme to analyze tremor disorders. Oscillations are simulated by changing the intrinsic membrane properties of burst neurons. The authors use a model neuron of Hodgkin-Huxley type with added hyperpolarization activated cation current Ih low threshold calcium current It and GABA glycine mediated chloride currents. Post-inhibitory rebound is taken into account. The model includes a reciprocally innervated circuit of neurons projecting to pairs of agonist and antagonist muscles. A set of four burst neurons has been simulated inhibitory agonist inhibitory antagonist excitatory agonist and excitatory antagonist. The model fits well with the known anatomical organization of neural circuits for limb movements in premotor motor areas and .
