Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Interdependency of CEACAM-1, -3, -6, and -8 induced human neutrophil adhesion to endothelial cells | Journal of Translational Medicine BioMed Central Research Open Access Interdependency of CEACAM-1 -3 -6 and -8 induced human neutrophil adhesion to endothelial cells Keith M Skubitz 1 and Amy PN Skubitz2 Address rrhe Department of Medicine the University of Minnesota Medical School and the Masonic Cancer Center Minneapolis MN 55455 USA and 2The Department of Laboratory Medicine and Pathology the University of Minnesota Medical School and the Masonic Cancer Center Minneapolis MN 55455 USA Email Keith M Skubitz - skubi001@ Amy PN Skubitz - skubi002@ Corresponding author Published 10 December 2008 Received 12 August 2008 _ -T_OAAO I io iiA-ra ro-rr z -70 Accepted 10 December 2008 Journal of Translational Medicine 2008 6 78 doi l479-5876-6-78 This article is available from http content 6 1 78 2008 Skubitz and Skubitz licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Members of the carcinoembryonic antigen family CEACAMs are widely expressed and depending on the tissue capable of regulating diverse functions including tumor promotion tumor suppression angiogenesis and neutrophil activation. Four members of this family CEACAM1 cEAcAM8 CEACAM6 and CEACAM3 recognized by CD66a CD66b CDÓỏc and CD66d mAbs respectively are expressed on human neutrophils. CD66a CD66b CD66c and CD66d antibodies each increase neutrophil adhesion to human umbilical vein endothelial cell monolayers. This increase in neutrophil adhesion caused by CD66 antibodies is blocked by CD18 mAbs and is associated with upregulation of CD1 1 CD 18 on the neutrophil surface. To examine potential interactions of CEACAMs in neutrophil signaling the effects on neutrophil adhesion to human .
