Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : High correlation of the proteome patterns in bone marrow and peripheral blood blast cells in patients with acute myeloid leukemia | Journal of Translational Medicine BioMed Central Open Access High correlation of the proteome patterns in bone marrow and peripheral blood blast cells in patients with acute myeloid leukemia Gero Hutter 1 Anne Letsch1 Daniel Nowak1 Julia Poland2 Pranav Sinha2 Eckhard Thiel1 and Wolf-K Hofmann1 Address Department of Internal Medicine III Hematology Onkology Charité Berlin Campus Benjamin Franklin Berlin Germany and institute of Laboratory Medicine and Clinical Chemistry LKH Klagenfurt Austria Email Gero Hutter - Anne Letsch - Daniel Nowak - Julia Poland - Pranav Sinha - Eckhard Thiel - Wolf-K Hofmann - Corresponding author Published 15 January 2009 Received 12 September 2008 Journal of Translational Medicine 2009 7 7 doi l479-5876-7-7 Accepted I5 January 2009 This article is available from http content 7 l 7 2009 Hutter et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background When comparing myelogenous blasts from bone marrow and peripheral blood immunophenotyping usually show a strong correlation of expression of surface antigens. However it remains to be determined whether this correlation also exists on the level of protein expression. Method Therefore we investigated both bone marrow and peripheral blood blast cells from six patients with newly diagnosed acute myeloid leukemia AML using conventional two-dimensional electrophoresis in the first dimension and linear polyacrylamide gels l2 in the second dimension. Proteins were .
