Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Heterogeneous activation of the TGFβ pathway in glioblastomas identified by gene expression-based classification using TGFβ-responsive genes | Journal of Translational Medicine BioMed Central Research Heterogeneous activation of the TGFP pathway in glioblastomas identified by gene expression-based classification using TGFP-responsive genes Xie LXu 1 2 and Ann M Kapoun1 3 Address 1Biomarker R D Scios Inc Fremont California USA 2Current address Experimental Medicine Johnson Johnson Pharmaceutical Research and Development San Diego California USA and 3Current address Department of Translational Medicine OncoMed Pharmaceuticals Inc Redwood City California USA Email Xie L Xu - lxu@ Ann M Kapoun - Corresponding author Open Access Published 3 February 2009 Received I October 2008 Journal of Translational Medicine 2009 7 12 doi 1479-5876-7-12 Accepted 3 February 2009 This article is available from http content 7 1 12 2009 Xu and Kapoun licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background TGFP has emerged as an attractive target for the therapeutic intervention of glioblastomas. Aberrant TGFP overproduction in glioblastoma and other high-grade gliomas has been reported however to date none of these reports has systematically examined the components of TGFP signaling to gain a comprehensive view of TGFP activation in large cohorts of human glioma patients. Methods TGFP activation in mammalian cells leads to a transcriptional program that typically affects 5-10 of the genes in the genome. To systematically examine the status of TGFP activation in high-grade glial tumors we compiled a gene set of transcriptional response to TGFP stimulation from tissue culture and in vivo animal studies. These genes were used to examine the status of TGFP activation in high-grade gliomas including a large
