Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Gene and microRNA analysis of neutrophils from patients with polycythemia vera and essential thrombocytosis: down-regulation of micro RNA-1 and -133a | Journal of Translational Medicine BioMed Central Open Access Gene and microRNA analysis of neutrophils from patients with polycythemia vera and essential thrombocytosis down-regulation of micro RNA-1 and -133a Stefanie Slezak1 Ping Jin1 Lorraine Caruccio1 Jiaqiang Ren1 Michael Bennett2 Nausheen Zia1 Sharon Adams1 Ena Wang1 Joao Ascensao3 Geraldine Schechter3 and David Stroncek 1 Address Department of Transfusion Medicine Clinical Center National Institutes of Health Bethesda Maryland USA 2Department of Hematology Emek Hospital Afula Israel and 3Hematology Section Veterans Affairs Medical Center Washington DC USA Email Stefanie Slezak - Ping Jin - pjin@ Lorraine Caruccio - lcaruccio@ Jiaqiang Ren - renj@ Michael Bennett - benet_m@ Nausheen Zia - zianau@ Sharon Adams - sadams1@ Ena Wang - EWang@ Joao Ascensao - Geraldine Schechter - David Stroncek - dstroncek@ Corresponding author Published 4 June 2009 Received 17 March 2009 Journal of Translational Medicine 2009 7 39 doi l479-5876-7-39 Accepted 4 June 2009 This article is available from http content 7 1 39 2009 Slezak et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Since the V617F mutation in JAK2 may not be the initiating event in myeloprofilerative disorders MPDs we compared molecular changes in neutrophils from patients with polycythemia vera PV and essential thrombocythosis ET to neutrophils stimulated by G-CSF administration and to normal unstimulated neutrophils Methods A gene expression oligonucleotide microarray with more than 35 000 probes and a microRNA .
