Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Recent progress towards development of effective systemic chemotherapy for the treatment of malignant brain tumors | Journal of Translational Medicine BioMed Central Open Access Recent progress towards development of effective systemic chemotherapy for the treatment of malignant brain tumors Hemant Sarin Address National Institute of Biomedical Imaging and Bioengineering National Institutes of Health Bethesda Maryland USA Email Hemant Sarin - sarinh@ Published I September 2009 Received 5 August 2009 _ _-mno .A I IO ÍIz-rn roi 1 11 Accepted 1 September 2009 Journal of Translational Medicine 2009 7 77 doi 1479-5876-7-77 This article is available from http content 7 1 77 2009 Sarin licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Systemic chemotherapy has been relatively ineffective in the treatment of malignant brain tumors even though systemic chemotherapy drugs are small molecules that can readily extravasate across the porous blood-brain tumor barrier of malignant brain tumor microvasculature. Small molecule systemic chemotherapy drugs maintain peak blood concentrations for only minutes and therefore do not accumulate to therapeutic concentrations within individual brain tumor cells. The physiologic upper limit of pore size in the blood-brain tumor barrier of malignant brain tumor microvasculature is approximately 12 nanometers. Spherical nanoparticles ranging between 7 nm and 10 nm in diameter maintain peak blood concentrations for several hours and are sufficiently smaller than the 12 nm physiologic upper limit of pore size in the blood-brain tumor barrier to accumulate to therapeutic concentrations within individual brain tumor cells. Therefore nanoparticles bearing chemotherapy that are within the 7 to 10 nm size range can be used to deliver therapeutic .
