Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Main roads to melanoma | Journal of Translational Medicine BioMed Central Open Access Main roads to melanoma Giuseppe Palmieri1 Mariaelena Capone2 Maria Libera Ascierto2 Giusy Gentilcore2 David F Stroncek3 Milena Casula1 Maria Cristina Sini1 Marco Palla2 Nicola Mozzillo2 and Paolo A Ascierto 2 Address Ustituto di Chimica Biomolecolare Consiglio Nazionale delle Ricerche CNR Sassari Italy 2Istituto Nazionale Tumori Fondazione Pascale Napoli Italy and 3Cell Processing Section Department of Transfusion Medicine Clinical Center NIH Bethesda MD USA Email Giuseppe Palmieri - gpalmieri@ Mariaelena Capone - marilenacapone@ Maria Libera Ascierto - asciertoml@ Giusy Gentilcore - David F Stroncek - pasciert@ Milena Casula - casulam@ Maria Cristina Sini - Marco Palla - pallamarco@ Nicola Mozzillo - nimozzi@ Paolo A Ascierto - Corresponding author Published 14 October 2009 Received 30 June 2009 Journal of Translational Medicine 2009 7 86 doi l479-5876-7-86 Accepted 14 October 2009 This article is available from http content 7 1 86 2009 Palmieri et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The characterization of the molecular mechanisms involved in development and progression of melanoma could be helpful to identify the molecular profiles underlying aggressiveness clinical behavior and response to therapy as well as to better classify the subsets of melanoma patients with different prognosis and or clinical outcome. Actually some aspects regarding the main molecular changes responsible for the onset as well as the progression of melanoma toward a more aggressive phenotype have