Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer | Zhou et al. Journal of Translational Medicine 2010 8 13 http content 8 1 13 RESEARCH JOURNAL OF TRANSLATIONAL MEDICINE Open Access The density of macrophages in the invasive front is inversely correlated to liver metastasis in colon cancer I z t 7 I 11 2 DI I I I z t z t 1 2 V I r 11 I A i I 1 2 I U VI 1 2 I I z I_11 I I I_I r I I 1 4 7 IA1 z i 1 2 I A A I U 1 ỉ p. r I I 1 2 Qiang Zhou Rui-Qing reng Xiao-Jun wu Qing Aid Jing-nui Hou Ya Ding Qi-Ming Zhou Xing Zhang1 2 Zhi-Zhong Pang1 3 De-Sen Wan1 3 Yi-Xin Zeng1 2 Xiao-Shi Zhang1 2 Abstract Background Although an abundance of evidence has indicated that tumor-associated macrophages TAMs are associated with a favorable prognosis in patients with colon cancer it is still unknown how TAMs exert a protective effect. This study examined whether TAMs are involved in hepatic metastasis of colon cancer. Materials and methods One hundred and sixty cases of pathologically-confirmed specimens were obtained from colon carcinoma patients with TNM stage IIIB and IV between January 1997 and July 2004 at the Cancer Center of Sun Yat-Sen University. The density of macrophages in the invasive front CD68TFHotspot was scored with an immunohistochemical assay. The relationship between the CD68TFHotspot and the clinicopathologic parameters the potential of hepatic metastasis and the 5-year survival rate were analyzed. Results TAMs were associated with the incidence of hepatic metastasis and the 5-year survival rate in patients with colon cancers. Both univariate and multivariate analyses revealed that the CD68TFHotspot was independently prognostic of survival. A higher 5-year survival rate among patients with stage IIIB after radical resection occurred in patients with a higher macrophage infiltration in the invasive front than in those with a lower macrophage infiltration . Most importantly the CD68TFHotspot was associated with both the potential of hepatic metastasis and the interval between .
