Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Prognostic significance of Oct4 and Sox2 expression in hypopharyngeal squamous cell carcinoma | Ge et al. Journal of Translational Medicine 2010 8 94 http content 8 1 94 RESEARCH JOURNAL OF TRANSLATIONAL MEDICINE Open Access Prognostic significance of Oct4 and Sox2 expression in hypopharyngeal squamous cell carcinoma 1 2t 1 2t 1 3t 1 4 1 2 1 2 1 2 1 2 Nan Ge Huan-Xin Lin Xiang-Sheng Xiao Ling Guo Hui-Min Xu Xin Wang ling Jin Xiu-Yu Cai Yi Liang 1 Wei-Han Hu1 2 Tiebang Kang1 Abstract Background Oct4 and Sox2 are two major transcription factors related to the stem cell self-renewal and differentiation. The aim of this study was to examine the association between Oct4 and Sox2 expression levels with both the clinicopathological characteristics and prognoses of patients with hypopharyngeal squamous cell carcinoma. Method Tumor tissue samples from 85 patients with hypopharyngeal squamous cell carcinoma were collected and the clinical follow-up data of these patients were recorded and expression status of Oct4 and Sox2 were examined in these tissue samples by immunohistochemistry IHC . Results Oct4 expression was found to be an independent predictive factor for overall survival p in patients with hypopharyngeal squamous cell carcinoma and was independently related to loco-regional control p . Although Sox2 expression status showed no significant association with overall survival p disease-free survival p or loco-regional control p when using a subgroup analysis the subgroup with both high Oct4 and Sox2 expression had the best prognosis p . Sox2 expression could be a potential prognostic predictor for patients with hypopharyngeal squamous cell carcinoma. Simultaneous analyses of Oct4 and Sox2 expression could be more effective in evaluating the prognoses of patients with hypopharyngeal squamous cell carcinoma. Conclusion Oct4 expression is an independent predictive factor for patients with hypopharyngeal squamous cell carcinoma suggesting that Oct4 expression may be a useful indicator for predicting
