Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: The emerging role of insulin-like growth factor 1 receptor (IGF1r) in gastrointestinal stromal tumors (GISTs) | Pantaleo et al. Journal of Translational Medicine 2010 8 117 http content 8 1 117 JOURNAL OF TRANSLATIONAL MEDICINE COMMENTARY Open Access The emerging role of insulin-like growth factor 1 receptor IGF1r in gastrointestinal stromal tumorS GISTs Maria A Pantaleo1 2 Annalisa Astolfi1 2 Margherita Nannini1 Guido Biasco1 2 Abstract Recent years have seen a growing interest in insulin-like growth factor 1 receptor IGF1R in medical oncology. Interesting data have been reported also on IGF1r in gastrointestinal stromal tumors GISTs especially in children and in young adult patients whose disease does not harbour mutations on KIT and PDGFRA and are poorly responsive to conventional therapies. However it is too early to reach conclusions on IGF1R as a novel therapeutic target in GIST because the receptor s biological role is still to be defined and the clinical significance in patients needs to be studied in larger studies. We update and comment the current literature on IGF1R in GISTs and discuss the future perspectives in this promising field. Introduction Recent years have seen a growing interest in insulin-like growth factor 1 receptor IGF1R in medical oncology. IGF1R is a tyrosine kinase receptor that binds both IGF1 and IGF2 1 . After ligand binding the tyrosine kinase domain is activated and stimulates the intracellular signaling pathways that control the proliferation rate and apoptosis Figure 1 . Two key signal-transduction networks have been identified GPTase Ras-Raf-ERK MAPK and PI3K-AKT mTOR 2 . The IGF system plays a key role in the growth and development of normal tissue. However aberrations of this molecular pathway such as overexpression of IGF1R elevated plasma levels of IGF1 loss of IGF2 imprinting or genetic polymorphisms of the gene encoding IGF1 have been found in many cancers affecting multiple aspects of malignancy such as tumor growth and metastases 3 4 . The biologic role of the IGF system in rhabdomyosarcomas .
