Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Early detection of urothelial premalignant lesions using hexaminolevulinate fluorescence cystoscopy in high risk patients | Blanco et al. Journal of Translational Medicine 2010 8 122 http content 8 1 122 JOURNAL OF TRANSLATIONAL MEDICINE METHODOLOGY Open Access Early detection of urothelial premalignant lesions using hexaminolevulinate fluorescence cystoscopy in high risk patients 1 1 2 3 1 Salvatore Blanco Marco Raber Biagio Eugenio Leone Luca Nespoli Marco Grasso Abstract Background To evaluate fluorescence cystoscopy with hexaminolevulinate HAL in the early detection of dysplasia DYS and carcinoma in situ CIS in select high risk patients. Methods We selected 30 consecutive bladder cancer patients at high risk for progression. After endoscopic resection all patients received a induction BCG schedule when needed and b white light and fluorescence cystoscopy after 3 months. HAL at doses of 85 mg GE Healthcare Buckinghamshire United Kingdom dissolved in 50 ml of solvent to obtain an 8 mmol L solution was instilled intravesically with a 12 Fr catheter into an empty bladder and left for 90 minutes. The solution was freshly prepared immediately before instillation. Cystoscopy was performed within 120 minutes of bladder emptying. Standard and fluorescence cystoscopy was performed using a double light system Combilight PDD light source 5133 Wolf Germany which allowed an inspection under both white and blue light. Results The overall incidence was dysplasia CIS and superficial transitional cell cancer. In 21 patients HAL cystoscopy was positive with one or more fluorescent flat lesions. Of the positive cases there were 4 CIS 10 DYS 2 association of CIS and DYS 4 well-differentiated non-infiltrating bladder cancers and 1 chronic cystitis. In 9 patients with negative HAL results random biopsies showed 1 CIS and 1 DYS. HAL cystoscopy showed sensitivity and specificity with positive predictive value and negative predictive value. Conclusion Photodynamic diagnosis should be considered a very important tool in the diagnosis of .
