Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Future research and therapeutic applications of human stem cells: general, regulatory, and bioethical aspects | Liras Journal of Translational Medicine 2010 8 131 http content 8 1 131 TRANSLATIONAL MEDICINE REVIEW Open Access Future research and therapeutic applications of human stem cells general regulatory and bioethical aspects Antonio Liras Abstract There is much to be investigated about the specific characteristics of stem cells and about the efficacy and safety of the new drugs based on this type of cells both embryonic as adult stem cells for several therapeutic indications cardiovascular and ischemic diseases diabetes hematopoietic diseases liver diseases . Along with recent progress in transference of nuclei from human somatic cells as well as iPSC technology has allowed availability of lineages of all three germ layers genetically identical to those of the donor patient which permits safe transplantation of organ-tissue-specific adult stem cells with no immune rejection. The main objective is the need for expansion of stem cell characteristics to maximize stem cell efficacy . the proper selection of a stem cell and the efficacy maximum effect and safety of stem cell derived drugs. Other considerations to take into account in cell therapy will be the suitability of infrastructure and technical staff biomaterials production costs biobanks biosecurity and the biotechnological industry. The general objectives in the area of stem cell research in the next few years are related to identification of therapeutic targets and potential therapeutic tests studies of cell differentiation and physiological mechanisms culture conditions of pluripotent stem cells and efficacy and safety tests for stem cellbased drugs or procedures to be performed in both animal and human models in the corresponding clinical trials. A regulatory framework will be required to ensure patient accessibility to products and governmental assistance for their regulation and control. Bioethical aspects will be required related to the scientific and therapeutic relevance .
