Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Clearance of low levels of HCV viremia in the absence of a strong adaptive immune response | Virology Journal BioMed Central Open Access Study protocol Clearance of low levels of HCV viremia in the absence of a strong adaptive immune response Manuela F Meyer1 Marc Lehmann2 Markus Cornberg1 Johannes Wiegand1 Michael P Manns1 Christoph Klade3 and Heiner Wedemeyer 1 Address Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School D- 30623 Hannover Germany 2Jugendanstalt Hameln Tundernsche Strafie 50 31789 Hameln Germany and 3Clinical Immunology T-cell epitope Identifcation Program Intercell AG Campus Vienna Biocenter 6 1030 Wien Austria Email Manuela F Meyer - Marc Lehmann - Markus Cornberg - Johannes Wiegand - Michael P Manns - Christoph Klade - cklade@ Heiner Wedemeyer - Corresponding author Published II June 2007 Received 21 August 2006 Accepted 11 June 2007 Virology Journal 2007 4 58 doi 1 743-422X-4-58 This article is available from http content 4 1 58 2007 Meyer et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Spontaneous clearance of hepatitis C virus HCV has frequently been associated with the presence of HCV-specific cellular immunity. However there had been also reports in chimpanzees demonstrating clearance of HCV-viremia in the absence of significant levels of detectable HCV-specific cellular immune responses. We here report seven asymptomatic acute hepatitis C cases with peak HCV-RNA levels between 300 and copies ml who all cleared HCV-RNA spontaneously. Patients were identified by a systematic screening of 1176 consecutive new .
