Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Thottapalayam virus is genetically distant to the rodent-borne hantaviruses, consistent with its isolation from the Asian house shrew (Suncus murinus) | Virology Journal BioMed Central Open Access Thottapalayam virus is genetically distant to the rodent-borne hantaviruses consistent with its isolation from the Asian house shrew Suncus murinus Pragya D Yadav1 2 Martin J Vincent1 and Stuart T Nichol 1 Address 1Special Pathogen Branch Division of Viral and Rickettsial Diseases National Center for Zoonotic Vector-borne and Enteric Diseases Centers for Disease Control and Prevention Atlanta GA 30333 USA and 2Microbial Containment Complex National Institute of Virology 130 1 Sus Road Pashan Pune 21 Maharashtra 411021 India Email Pragya D Yadav - yadavpd@ MartinJVincent-mvincent@ Stuart T Nichol - snichol@ Corresponding author Published 21 August 2007 Received 27 July 2007 Virology Journal 2007 4 80 doi 1743-422X-4-80 Accepted 21 August 2007 This article is available from http content 4 1 80 2007 Yadav et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Thottapalayam TPM virus belongs to the genus Hantavirus family Bunyaviridae. The genomes of hantaviruses consist of three negative-stranded RNA segments S M and L encoding the virus nucleocapsid N glycoprotein Gn Gc and polymerase L proteins respectively. The genus Hantavirus contains predominantly rodent-borne viruses with the prominent exception of TPM virus which was isolated in India in 1964 from an insectivore Suncus murinus commonly referred to as the Asian house shrew or brown musk shrew. Analysis of the available TPM virus S 1530 nt RNA genome segment sequence and the newly derived M 3621 nt and L 6581 nt segment sequences demonstrate that the entire TPM virus genome is very unique. Remarkably high sequence differences are seen at the nucleotide up to S - 47 M -
