Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Does Japanese encephalitis virus share the same cellular receptor with other mosquito-borne flaviviruses on the C6/36 mosquito cells? | Virology Journal BioMed Central Hypothesis Open Access Does Japanese encephalitis virus share the same cellular receptor with other mosquito-borne flaviviruses on the C6 36 mosquito cells Junping Rent Tianbing Dingt Wei Zhang Jianhua Song and Wenyu Ma Address Department of Microbiology Fourth Military Medical University 17 Changle West Road Xi an 710032 People s Republic of China Email Junping Ren - junpingr@ Tianbing Ding - dingtb@ Wei Zhang - zhangw90@ Jianhua Song - wswjx@ Wenyu Ma - mawenyu@ Corresponding author tEqual contributors Published 6 September 2007 Received II June 2007 Accepted 6 September 2007 Virology Journal 2007 4 83 doi 1743-422X-4-83 This article is available from http content 4 1 83 2007 Ren et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Japanese encephalitis virus JEV is a member of mosquito-borne Flaviviridae. To date the mechanisms of the early events of JEV infection remain poorly understood and the cellular receptors are unidentified. There are evidences that the structure of the virus attachment proteins VAP envelope glycoprotein of mosquito-borne flaviviruses is very similar and the vector-virus interaction of mosquito-borne flaviviruses is also very similar. Based on the studies previously demonstrated that the similar molecules present on the mosquito cells involved in the uptake process of JEV West Nile virus WNV and Dengue virus DV it is proposed that the same receptor molecules for mosquito-borne flaviviruses JEV WNV and DV may present on the surface of C6 36 mosquito cells. By co-immunoprecipitation assay we investigated a 74-KDa protein on the C6 36 cells binds JEV and the mass spectrometry .
