Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Anti-inflammatory effects of nicotine in obesity and ulcerative colitis | Lakhan and Kirchgessner Journal of Translational Medicine 2011 9 129 http content 9 1 129 JOURNAL OF TRANSLATIONAL MEDICINE REVIEW Open Access Anti-inflammatory effects of nicotine in obesity and ulcerative colitis Shaheen E Lakhan 1 and Annette Kirchgessner1 2 Abstract Cigarette smoke is a major risk factor for a number of diseases including lung cancer and respiratory infections. Paradoxically it also contains nicotine an anti-inflammatory alkaloid. There is increasing evidence that smokers have a lower incidence of some inflammatory diseases including ulcerative colitis and the protective effect involves the activation of a cholinergic anti-inflammatory pathway that requires the a7 nicotinic acetylcholine receptor a7nAChR on immune cells. Obesity is characterized by chronic low-grade inflammation which contributes to insulin resistance. Nicotine significantly improves glucose homeostasis and insulin sensitivity in genetically obese and diet-induced obese mice which is associated with suppressed adipose tissue inflammation. Inflammation that results in disruption of the epithelial barrier is a hallmark of inflammatory bowel disease and nicotine is protective in ulcerative colitis. This article summarizes current evidence for the anti-inflammatory effects of nicotine in obesity and ulcerative colitis. Selective agonists for the a7nAChR could represent a promising pharmacological strategy for the treatment of inflammation in obesity and ulcerative colitis. Nevertheless we should keep in mind that the anti-inflammatory effects of nicotine could be mediated via the expression of several nAChRs on a particular target cell. Keywords a7-nicotinic acetylcholine receptor ulcerative colitis enteric nervous system pro-inflammatory cytokines Introduction The major addictive component of tobacco nicotine exerts anti-inflammatory effects in multiple cell types and has been shown to benefit various disorders in which an inflammation-related .
