Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Combination of cyclosporine and erythropoietin improves brain infarct size and neurological function in rats after ischemic stroke | Yuen et al. Journal of Translational Medicine 2011 9 141 http content 9 1 141 JOURNAL OF TRANSLATIONAL MEDICINE RESEARCH Open Access Combination of cyclosporine and erythropoietin improves brain infarct size and neurological function in rats after ischemic stroke Chun-Man Yuen1 Cheuk-Kwan Sun2 Yu-Chun Lin3 Li-Teh Chang4 Ying-Hsien Kao3 Chia-Hung Yen5 11 T-I I II T-I r I 7- 6 I 711 I_I Í-17- 11 u6 c 11 í n 11 - 6 I I I cl -7 I 118 _I I i I- 6 8 t Yung-Lung Chen izu-Hsien isai Sarah Chua Pei-Lin Shao Steve Leu and Hon-Kan Yip Abstract Background This study tested the superiority of combined cyclosporine A CsA -erythropoietin EPO therapy compared with either one in limiting brain infarction area BIA and preserving neurological function in rat after ischemic stroke IS . Methods Fifty adult-male SD rats were equally divided into sham control group 1 IS plus intra-peritoneal physiological saline at 24 48 h after IS group 2 IS plus CsA mg kg at 24h intra-peritoneal group 3 IS plus EPO 5 000IU kg at 24 48h subcutaneous group 4 combined CsA and EPO same route and dosage as groups 3 and 4 treatment group 5 after occlusion of distal left internal carotid artery. Results BIA on day 21 after acute IS was higher in group 2 than in other groups and lowest in group 5 all p . The sensorimotor functional test showed higher frequency of left turning in group 2 than in other groups and lowest in group 5 all p . mRNA and protein expressions of apoptotic markers and number of apoptotic nuclei on TUNEL were higher in group 2 than in other groups and lowest in group 1 and 5 whereas the anti-apoptotic markers exhibited an opposite trend all p . The expressions of inflammatory and oxidized protein were higher in group 2 than in other groups and lowest in group 1 and 5 whereas anti-inflammatory markers showed reversed changes in group 1 and other groups all p . The number of aquaporin-4 and glial fibrillary acid protein .
