Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Modulation of macrophage functions by sheeppox virus provides clues to understand interaction of the virus with host immune system | Virology Journal BioMed Central Research Open Access Modulation of macrophage functions by sheeppox virus provides clues to understand interaction of the virus with host immune system Abdel-Aziz S Abu-EL-SaadX1 and Ahmed S Abdel-Moneim t2 Address Department of Zoology Faculty of Science Cairo University Beni-Suef Egypt and 2Department of Virology Faculty of Veterinary Medicine Cairo University Beni-Suef 62511 Egypt Email Abdel-Aziz S Abu-EL-Saad - elsaad1@ Ahmed S Abdel-Moneim - a_s_abdel_moneim@ Corresponding author fEqual contributors Published 22 March 2005 Received 09 March 2005 Accepted 22 March 2005 Virology Journal 2005 2 22 doi 1743-422X-2-22 This article is available from http content 2 1 22 2005 Abu-EL-Saad and Abdel-Moneim licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Poxviruses encode a range of immunomodulatory genes to subvert or evade the challenges posed by the innate and adaptive immune responses. However the inactivated poxviruses possessed immunostimulating capacity and were used as a prophylactic or metaphylactic application that efficiently reduced susceptibility to infectious diseases in different species. This fact is intensively studied in different genera of poxviruses. However little is known about the basic mechanisms adopted by sheeppox virus SPPV . SPPV causes an acute disease of sheep that recently has been observed to reinfect its host in spite of vaccination. Results By injecting inactivated or attenuated sheeppox virus SPPV vaccine in adult male Swiss mice SPPV was found to reduce macrophages functions in a local event that occurs at the site of application 12 h after vaccine administration as indicated by increased level of .
