Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Stereophysicochemical variability plots highlight conserved antigenic areas in Flaviviruses | Virology Journal BioMed Central Methodology Open Access Stereophysicochemical variability plots highlight conserved antigenic areas in Flaviviruses Catherine H Schein 1 3 Bin Zhou1 and Werner Braun1 2 Address 1Sealy Center for Structural Biology Department of Human Biology Chemistry and Genetics University of Texas Medical Branch at Galveston TX USA 2Sealy Center for Vaccine Development Department of Human Biology Chemistry and Genetics University of Texas Medical Branch at Galveston TX USA and 3Department of Microbiology and Immunology University of Texas Medical Branch at Galveston TX USA Email Catherine H Schein - chschein@ Bin Zhou - bizhou@ Werner Braun - webraun@ Corresponding author Published 21 April 2005 Received 21 March 2005 Accepted 21 April 2005 Virology Journal 2005 2 40 doi l 743-422X-2-40 This article is available from http content 2 1 40 2005 Schein et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Flaviviruses which include Dengue DV and West Nile WN mutate in response to immune system pressure. Identifying escape mutants variant progeny that replicate in the presence of neutralizing antibodies is a common way to identify functionally important residues of viral proteins. However the mutations typically occur at variable positions on the viral surface that are not essential for viral replication. Methods are needed to determine the true targets of the neutralizing antibodies. Results Stereophysicochemical variability plots SVPs 3-D images of protein structures colored according to variability as determined by our PCPMer program were used to visualize residues conserved in their physical chemical properties PCPs near escape mutant .
