Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Evidence that spontaneous reactivation of herpes virus does not occur in mice | Virology Journal BioMed Central Research Open Access Evidence that spontaneous reactivation of herpes virus does not occur in mice Bryan M Gebhardt 1 and William P Halford2 Address 1LSU Eye Center Louisiana State University Health Sciences Center New Orleans LA 70112 USA and 2Department of Veterinary Microbiology Montana State University Bozeman MT 59718 USA Email Bryan M Gebhardt - bgebha@ William P Halford - halford@ Corresponding author Published 18 August 2005 Received 17 June 2005 Accepted 18 August 2005 Virology Journal 2005 2 67 doi 1743-422X-2-67 This article is available from http content 2 1 67 2005 Gebhardt and Halford licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Some species including humans and rabbits exhibit periodic viral reactivation and shed infectious virus at the infected end organ. Mice may be an exception because spontaneous shedding of infectious virus rarely if ever occurs. However spontaneous molecular reactivation . the expression of a few viral genes and the synthesis of the viral glycoproteins coded for by these genes has been reported. This finding has prompted the assumption that molecular reactivation is an indicator of reactivation and the production of infectious virus. The goal of this study was to differentiate between viral gene expression during latency and the episodic production of infectious virus in mice. Results Viral reactivation and infection were not seen in herpes simplex virus type 1 HSV-1 latent ganglion graft recipient BALB c scid or immunocompetent BALB c mice which survived the 65-day observation period with no evidence of viral infection although the immunocompetent mice developed cellular and humoral
