Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Cyclic cidofovir (cHPMPC) prevents congenital cytomegalovirus infection in a guinea pig model | Virology Journal BioMed Central Research Cyclic cidofovir cHPMPC prevents congenital cytomegalovirus infection in a guinea pig model Mark R Schleiss Jodi L Anderson and Alistair McGregor Open Access Address Division of Infectious Diseases University of Minnesota Department of Pediatrics Center for Infectious Diseases and Microbiology Translational Research 2001 6th Street SE McGuire Translational Research Facility Minneapolis Minnesota 55455 USA Email Mark R Schleiss - schleiss@ Jodi L Anderson - kaise024@ Alistair McGregor - mcgre077@ Corresponding author Published 01 March 2006 Received 30 December 2005 Accepted 01 March 2006 Virology Journal 2006 3 9 doi l743-422X-3-9 This article is available from http content 3 1 9 2006 Schleiss et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background Congenital cytomegalovirus CMV infection is a major public health problem. Antiviral therapies administered during pregnancy might prevent vertical CMV transmission and disease in newborns but these agents have not been evaluated in clinical trials. The guinea pig model of congenital CMV infection was therefore used to test the hypothesis that antiviral therapy using the agent agent cyclic cidofovir cHPMPC could prevent congenital CMV infection. Results Pregnant outbred Hartley guinea pigs were challenged in the early-third trimester with guinea pig CMV GPCMV and treated with placebo or the antiviral agent cyclic cidofovir. To optimize detection of vertical infection an enhanced green fluorescent protein eGFP -tagged virus was employed. Compared to placebo cyclic cidofovir-treated dams and pups
