Tham khảo tài liệu 'human musculoskeletal biomechanics part 12', kỹ thuật - công nghệ, cơ khí - chế tạo máy phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | 9 Elements of Vascular Mechanics Gyorgy L Nadasy Clinical Experimental Research Department and Department of Human Physiology Semmelweis University Budapest 1. Introduction Between half and two thirds of human mortality in developed countries can be attributed to vascular diseases. Financial losses human sufferings are increasing with aging of the population. Vascular diseases develop when some or many vessels in the body are unable to fulfill their functions. The main function of blood vessels is essentially a mechanical one to conduct blood. Vessels are functioning in a unique in the body mechanical environment they are continuously subjected to hemodynamic forces to shear stress of flowing blood and to distending forces of pressure of the blood in the lumen. Vessels are so much adapted to these hemodynamic forces that it is impossible to understand their physiology pharmacology and pathology without taking into consideration the unavoidable biomechanical steps in the complicated pathways of cellular and systemic physiological vascular feed-back control loops to understand vascular drug action and pathomechanism of vascular disease Lee 2000 . Biomechanics is thus at the very core of all vascular sciences. That is reflected in the high number of papers published in the area. 35 000 papers listed in the Ovid Medline between 1948 and 2010 included knowledge on vascular mechanics in its narrower sense excluding papers dealing only with physiological and pharmacological means of vascular smooth muscle control . Deteriorating Windkessel function of the aged of the chronic hypertensive even after effective treatment of mean arterial pressure geometric biomechanical consequences of atheroscerotic focal remodeling of large arteries contractile and elastic remodeling of resistance arteries with aging with hypertension and with diabetes remodeling of venous networks and the venous wall in chronic venous disease inevitably draws the attention of clinicians and of .
