Ở người, tài sản hình thành nơ hoa hồng với hồng cầu cừu (E-nơ hoa hồng), và họ thiếu globulin miễn dịch dễ dàng phát hiện được bất kỳ lớp màng của chúng. Mặc dù sự trưởng thành của các tế bào T là thymusdependent, các tế bào phát sinh từ tiền thân trong tủy xương. | 278 XI. Disorders of the Immune System Connective Tissue and Joints Answers antibody synthesis by B lymphocytes. In humans they have the property of forming rosettes with sheep erythrocytes E-rosettes and they lack readily detectable immunoglobulin of any class on their membranes. Although the maturation of T cells is thymusdependent the cells arise from precursors in bone marrow. T cells constitute about 70 to 80 of blood lymphocytes they comprise greater than three-quarters of thymus lymphocytes but less than one-quarter of bone marrow lymphocytes. In lymph nodes they are found in paracortical areas. Specific monoclonal antibodies have been developed to characterize various subsets of T cells cells that carry a CD4 surface antigen are helper cells and those with a CD8 antigen function as cytotoxic-suppressor cells. Antibodydependent cell-mediated cytotoxicity is a property of a class of non-B non-T lymphocytes called large granular lymphocytes LGL cells . Antibody-dependent cell-mediated cytotoxicity can also be mediated by monocyte-macrophages and neutrophils. XI-42. The answer is E. Chap. 311 Although most clinicians believe that women with SLE should not become pregnant if they have active disease or advanced renal or cardiac disease the presence of SLE itself is not an absolute contraindication to pregnancy. The outcome of pregnancy is best for those women in remission at the time of conception. Even in women with quiescent disease exacerbations may occur usually in the first trimester and in the immediate postpartum period and 25 to 40 of pregnancies end in spontaneous abortion. Fetal loss rates are higher in patients with lupus anticoagulant or anticardiolipin antibodies. Flare-ups should be anticipated and vigorously treated with steroids. Steroids given throughout pregnancy also usually have no adverse effects on the child. In the case presented the fact that the woman had a life-threatening bout of disease a year ago would argue against stopping her .
