Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Novel Aβ peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease | Journal of Neuroinflammation BioMed Central Research Open Access Novel Ap peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer s disease Jun Zhou1 Maria I Fonseca1 Rakez Kayed1 Irma Hernandez1 Scott D Webster2 Ozkan Yazan1 David H Cribbs3 4 Charles G Glabe1 4 and Andrea J Tenner 1 4 5 Address Department of Molecular Biology and Biochemistry University of California Irvine CA 92697 USA 2Clarient Inc. San Juan Capistrano CA 92675 USA 3Department of Neurology University of California Irvine College of Medicine Irvine CA 92697 USA 4Institute for Brain Aging and Dementia University of California Irvine CA 92697 USA and 5Center for Immunology University of California Irvine CA 92697 USA Email Jun Zhou - junz@ Maria I Fonseca - mifonsec@ Rakez Kayed - rkayed@ Irma Hernandez - livhernandi@ Scott D Webster - swebster@ Ozkan Yazan - oyazan@ David H Cribbs - cribbs@ Charles G Glabe - cglabe@ Andrea J Tenner - atenner@ Corresponding author Published 07 December 2005 Received 16 September 2005 Journal ofNeuroinflammation 2005 2 28 doi l742-2094-2-28 Accepted 07 December 2005 This article is available from http content 2 1 28 2005 Zhou et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Alzheimer s disease a common dementia of the elder is characterized by accumulation of protein amyloid deposits in the brain. Immunization to prevent this accumulation has been proposed as a therapeutic possibility although adverse inflammatory reactions in human trials indicate the need for novel vaccination strategies. Method Here vaccination with novel amyloid peptide immunogens was .
