Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Secreted phospholipase A2 activity in experimental autoimmune encephalomyelitis and multiple sclerosis | Journal of Neuroinflammation BioMed Central Open Access Secreted phospholipase A2 activity in experimental autoimmune encephalomyelitis and multiple sclerosis Timothy J Cunningham 1 Lihua Yao1 Michelle Oetinger1 Laura Cort2 Elizabeth P Blankenhorn2 and Jeffrey I Greenstein3 Address Departments of Neurobiology and Anatomy Drexel University College of Medicine 2900 Queen Lane Philadelphia PA 19129 USA 2Department of Microbiology and Immunology Drexel University College of Medicine 2900 Queen Lane Philadelphia PA 19129 USA and 3The Multiple Sclerosis Institute 1740 South Street Philadelphia PA 19146 USA Email Timothy J Cunningham - tcunning@ Lihua Yao - lihuayao@ Michelle Oetinger - mo622@ Laura Cort - Elizabeth P Blankenhorn - Jeffrey I Greenstein - jigreenstein@ Corresponding author Published II September 2006 Received 10 June 2006 Accepted 11 September 2006 Journal of Neuroinflammation 2006 3 26 doi 1742-2094-3-26 This article is available from http content 3 1 26 2006 Cunningham et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background There is increased interest in the contribution of the innate immune system to multiple sclerosis MS including the activity of acute inflammatory mediators. The purpose of this study was to test the involvement of systemic secreted phospholipase A2 sPLA2 enzymes in experimental autoimmune encephalomyelitis EAE an MS model and to determine if enzyme activity is elevated in MS patients. Methods A non-invasive urinary assay was developed in order to monitor enzymatically
