Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis | Weinstock-Guttman et al. Journal of Neuroinflammation 2011 8 127 http content 8 1 127 JJOURNAL1 OF. NEUROINFLAMMATION RESEARCH Open Access Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis 1 12 1 1 Bianca Weinstock-Guttman Robert Zivadinov Naeem Mahfooz Ellen Carl Allison Drake Jaclyn Schneider Barbara Teter1 Sara Hussein2 Bijal Mehta1 Marc Weiskopf1 Jacqueline Durfee2 Niels Bergsland1 2 and Murali Ramanathan1 3 Abstract Background The breakdown of the blood-brain-barrier vascular endothelium is critical for entry of immune cells into the MS brain. Vascular co-morbidities are associated with increased risk of progression. Dyslipidemia elevated LDL and reduced HDL may increase progression by activating inflammatory processes at the vascular endothelium. Objective To assess the associations of serum lipid profile variables triglycerides high and low density lipoproteins HDL LDL and total cholesterol with disability and MRI measures in multiple sclerosis MS . Methods This study included 492 MS patients age years disease duration years with baseline and follow-up Expanded Disability Status Score EDSS assessments after a mean period of years. The associations of baseline lipid profile variables with disability changes were assessed. Quantitative MRI findings at baseline were available for 210 patients. Results EDSS worsening was associated with higher baseline LDL p and total cholesterol p levels with trends for higher triglyceride p HDL was not associated. A similar pattern was found for MSSS worsening. Higher HDL levels p were associated with lower contrast-enhancing lesion volume. Higher total cholesterol was associated with a trend for lower brain parenchymal fraction p . Conclusions Serum lipid profile has modest effects on disease progression in MS. Worsening disability is associated with higher levels of LDL total cholesterol and
