Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Trimellitic anhydride-conjugated serum albumin activates rat alveolar macrophages in vitro | Journal of Occupational Medicine and Toxicology BioMed Central Research Trimellitic anhydride-conjugated serum albumin activates rat alveolar macrophages in vitro Dingena L Valstar1 Marcel A Schijf1 Erietta Stelekati1 Frans P Nijkamp1 Nanne Bloksma1 2 and Paul AJ Henricks 1 Open Access Address Pharmacology and Pathophysiology Utrecht Institute for Pharmaceutical Sciences Faculty of Science Utrecht University Utrecht The Netherlands and 2Deparment of Biology Faculty of Science Utrecht University Utrecht The Netherlands Email Dingena L Valstar - ingevalstar@ Marcel A Schijf - Schijf@ Erietta Stelekati - estelekati@ Frans P Nijkamp - Nanne Bloksma - Paul AJ Henricks - Corresponding author Published 23 June 2006 Received 21 February 2006 Journal of Occupational Medicine and Toxicology 2006 1 13 doi l745-6673-l-l3 Accepted 23 June 2006 This article is available from http content l l l3 2006 Valstar et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Occupational exposure to airborne low molecular weight chemicals like trimellitic anhydride TMA can result in occupational asthma. Alveolar macrophages AMs are among the first cells to encounter these inhaled compounds and were previously shown to influence TMA-induced asthma-like symptoms in the Brown Norway rat. TMA is a hapten that will bind to endogenous proteins upon entrance of the body. Therefore in the present study we determined if TMA and TMA conjugated to serum albumin induced the production of the macrophage mediators nitric oxide NO tumour necrosis factor TNF and interleukin 6 IL-6 in vitro using the rat AM cell
