Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Site-specific analysis of gene expression in early osteoarthritis using the Pond-Nuki model in dogs | Journal of Orthopaedic Surgery and Research Research article BioMed Central Open Access Site-specific analysis of gene expression in early osteoarthritis using the Pond-Nuki model in dogs Aaron M Stoker 1 James L Cook1 Keiichi Kuroki2 and Derek B Fox1 Address The Comparative Orthopaedic Laboratory University of Missouri Columbia 379 E Campus Dr Columbia MO USA and 2Kansas State University Veterinary Diagnostic Laboratory Kansas State University 1800 Denison Avenue Manhattan KS USA Email Aaron M Stoker - stokera@ James L Cook - cookjl@ Keiichi Kuroki - kkuroki@ Derek B Fox - foxdb@ Corresponding author Published 10 October 2006 Received 16 March 2006 Journal of Orthopaedic Surgery and Research 2006 1 8 doi I749-799X-I-8 Accepted 10 October 2006 This article is available from http content 1 1 8 2006 Stoker et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Osteoarthritis OA is a progressive and debilitating disease that often develops from a focal lesion and may take years to clinically manifest to a complete loss of joint structure and function. Currently there is not a cure for OA but early diagnosis and initiation of treatment may dramatically improve the prognosis and quality of life for affected individuals. This study was designed to determine the feasibility of analyzing changes in gene expression of articular cartilage using the Pond-Nuki model two weeks after ACL-transection in dogs and to characterize the changes observed at this time point. Methods The ACL of four dogs was completely transected arthroscopically and the contralateral limb was used as the non-operated control. After two weeks the dogs were .
