Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Th1 type lymphocyte reactivity to metals in patients with total hip arthroplasty | Journal of Orthopaedic Surgery and Research Research article BioMed Central Open Access Thl type lymphocyte reactivity to metals in patients with total hip arthroplasty Nadim James Hallab 1 Marco Caicedo1 Alison Finnegan2 and Joshua J Jacobs1 Address department of Orthopedic Surgery Rush University Medical Center Chicago IL 60612 USA and department of Rheumatology Rush University Medical Center Chicago IL 60612 USA Email Nadim James Hallab - nhallab@ Marco Caicedo - stevepsmarco@ Alison Finnegan - Allison_Finnegan@ Joshua J Jacobs - jacobs@ Corresponding author Published 13 February 2008 Received 13 July 2007 Journal of Orthopaedic Surgery and Research 2008 3 6 doi 1749-799X-3-6 Accepted 13 February 2008 This article is available from http content 3 1 6 2008 Hallab et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background All prostheses with metallic components release metal debris that can potentially activate the immune system. However implant-related metal hyper-reactivity has not been well characterized. In this study we hypothesized that adaptive immunity reaction s particularly T-helper type 1 Th1 responses will be dominant in any metal-reactivity responses of patients with total joint replacements TJAs . We tested this hypothesis by evaluating lymphocyte reactivity to metal ions in subjects with and without total hip replacements using proliferation assays and cytokine analysis. Methods Lymphocytes from young healthy individuals without an implant or a history of metal allergy Group 1 n 8 were used to assess lymphocyte responses to metal challenge agents. In addition individuals Group 2 n 15 with well functioning total hip .
