Tham khảo tài liệu 'báo cáo hóa học: " clearance of an immunosuppressive virus from the cns coincides with immune reanimation and diversification"', luận văn - báo cáo phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Virology Journal BioMed Central Research Clearance of an immunosuppressive virus from the CNS coincides with immune reanimation and diversification Henning Lauterbach1 Phi Truong1 and Dorian B McGavern 1 2 Open Access Address 1Molecular and Integrative Neurosciences Department The Scripps Research Institute 10550 North Torrey Pines Rd. La Jolla CA 92037 USA and 2Harold L. Dorris Neurological Research Institute The Scripps Research Institute 10550 North Torrey Pines Rd. La Jolla CA 92037 USA Email Henning Lauterbach - hlauter@ Phi Truong - crazyuglymonkie@ Dorian B McGavern - mcgad@ Corresponding author Published 6 June 2007 Received 13 April 2007 Accepted 6 June 2007 Virology journal 2007 4 53 doi 186 1743-422X-4-53 This article is available from http content 4 1 53 2007 Lauterbach et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Once a virus infection establishes persistence in the central nervous system CNS it is especially difficult to eliminate from this specialized compartment. Therefore it is of the utmost importance to fully understand scenarios during which a persisting virus is ultimately purged from the CNS by the adaptive immune system. Such a scenario can be found following infection of adult mice with an immunosuppressive variant of lymphocytic choriomeningitis virus LCMV referred to as clone 13. In this study we demonstrate that following intravenous inoculation clone 13 rapidly infected peripheral tissues within one week but more slowly inundated the entire brain parenchyma over the course of a month. During the establishment of persistence we observed that genetically .
