Tham khảo tài liệu 'báo cáo hóa học: " development of a model for marburgvirus based on severe-combined immunodeficiency mice"', luận văn - báo cáo phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả | Virology Journal BioMed Central Research Open Access Development of a model for marburgvirus based on severe-combined immunodeficiency mice Kelly L Warfield Derron A Alves Steven B Bradfute Daniel K Reed Sean VanTongeren Warren V Kalina Gene G Olinger and Sina Bavari Address United States Army Medical Research Institute of Infectious Diseases Fort Detrick Maryland USA Email Kelly L Warfield - Derron A Alves - Steven B Bradfute - Daniel K Reed - Sean VanTongeren - Warren V Kalina - Gene G Olinger - Sina Bavari - Corresponding authors Published 25 October 2007 Received 16 July 2007 Accepted 25 October 2007 Virology Journal 2007 4 108 doi 1743-422X-4-108 This article is available from http content 4 1 108 2007 Warfield et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The filoviruses Ebola EBOV and Marburg MARV cause a lethal hemorrhagic fever. Human isolates of MARV are not lethal to immmunocompetent adult mice and to date there are no reports of a mouse-adapted MARV model. Previously a uniformly lethal EBOV-Zaire mouse-adapted virus was developed by performing 9 sequential passages in progressively older mice suckling to adult . Evaluation of this model identified many similarities between infection in mice and nonhuman primates including viral tropism for antigen-presenting cells high viral titers in the spleen and liver and an equivalent mean time to death. Existence of the EBOV mouse model has increased our understanding of host responses to filovirus infections and .
