Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: HBVRegDB: Annotation, comparison, detection and visualization of regulatory elements in hepatitis B virus sequences | Virology Journal BioMed Central Open Access Methodology HBVRegDB Annotation comparison detection and visualization of regulatory elements in hepatitis B virus sequences Nattanan Panjaworayan Stephan K Roessner Andrew E Firth and Chris M Brown Address Department of Biochemistry University of Otago Dunedin New Zealand Email Nattanan Panjaworayan - panna478@ Stephan K Roessner - Andrew E Firth - Chris M Brown - Corresponding author Published 17 December 2007 Received 17 October 2007 Accepted 17 December 2007 Virology Journal 2007 4 136 doi l743-422X-4-l36 This article is available from http content 4 l l36 2007 Panjaworayan et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background The many Hepadnaviridae sequences available have widely varied functional annotation. The genomes are very compact kb but contain multiple layers of functional regulatory elements in addition to coding regions. Key regions are subject to purifying selection as mutations in these regions will produce non-functional viruses. Results These genomic sequences have been organized into a structured database to facilitate research at the molecular level. HBVRegDB is a comparative genomic analysis tool with an integrated underlying sequence database. The database contains genomic sequence data from representative viruses. In addition to INSDC and RefSeq annotation HBVRegDB also contains expert and systematically calculated annotations . promoters and comparative genome analysis results . blastn tblastx . It also contains analyses based on .
