Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Tula hantavirus isolate with the full-length ORF for nonstructural protein NSs survives for more consequent passages in interferon-competent cells than the isolate having truncated NSs ORF | Virology Journal BioMed Central Research Tula hantavirus isolate with the full-length ORF for nonstructural protein NSs survives for more consequent passages in interferon-competent cells than the isolate having truncated NSs ORF Kirsi M Jaaskelainen 1 Angelina Plyusnina1 Ake Lundkvist2 3 Antti Vaheri1 and Alexander Plyusnin1 2 Address Department of Virology Haartman Institute PO Box 21 FIN-00014 University of Helsinki Helsinki Finland 2Swedish Institute for Infectious Disease Control S-171 82 Stockholm Sweden and 3Department of Microbiology Tumor and Cell Biology Karolinska Institutet S-171 77 Stockholm Sweden Email Kirsi M Jaaskelainen - Angelina Plyusnina - Ake Lundkvist - Antti Vaheri - Alexander Plyusnin - Corresponding author Open Access Published II January 2008 Received 19 October 2007 Accepted 1 1 January 2008 Virology journal 2008 5 3 doi 1743-422X-5-3 This article is available from http content 5 1 3 2008 Jaaskelainen et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The competitiveness of two Tula hantavirus TULV isolates TULV Lodz and TULV Moravia was evaluated in interferon IFN -competent and IFN-deficient cells. The two isolates differ in the length of the open reading frame ORF encoding the nonstructural protein NSs which has previously been shown to inhibit IFN response in infected cells. Results In IFN-deficient Vero E6 cells both TULV isolates survived equally well. In contrast in IFN-competent MRC5 cells TULV Lodz isolate that .
