Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Drug 9AA reactivates p21/Waf1 and Inhibits HIV-1 progeny formation | Virology Journal BioMed Central Research Open Access Drug 9AA reactivates p21 Waf1 and Inhibits HIV-1 progeny formation Weilin Wu1 Kylene Kehn-Hall1 Caitlin Pedati1 Lynnsey Zweier1 Iris Castro1 Zachary Klase1 Cynthia S Dowd2 Larisa Dubrovsky1 Michael Bukrinsky1 and Fatah Kashanchi 1 3 4 Address 1Frhe George Washington University Medical Center Department of Biochemistry and Molecular Biology Washington DC 20037 USA 2The George Washington University Department of ChemistryWashington DC 20037 USA 3The Institute for Genomic Research Rockville MD 20850 USA and 4The George Washington University . Keck Institute for Proteomics Technology and Applications Washington DC 20037 USA Email Weilin Wu - bcmwxw@ Kylene Kehn-Hall - bcmkwk@ Caitlin Pedati - bcmcsp@ Lynnsey Zweier - analaz@ Iris Castro - analaz@ Zachary Klase - bcmzak@ Cynthia S Dowd - cdowd@ Larisa Dubrovsky - mtmsxd@ Michael Bukrinsky - mtmmib@ Fatah Kashanchi - bcmfxk@ Corresponding author Published 18 March 2008 Received 30 January 2008 Accepted 18 March 2008 Virology Journal 2008 5 41 doi l 743-422X-5-4I This article is available from http content 5 1 41 2008 Wu et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract It has been demonstrated that the p53 pathway plays an important role in HIV-1 infection. Previous work from our lab has established a model demonstrating how p53 could become inactivated in HIV-1 infected cells through binding to Tat. Subsequently p53 was inactivated and lost its ability to transactivate its downstream target gene p21 waf1. P21 waf1 is a well-known cdk inhibitor CKI that can lead to cell cycle arrest upon DNA damage.
