Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: N-methylisatin-beta-thiosemicarbazone derivative (SCH 16) is an inhibitor of Japanese encephalitis virus infection in vitro and in vivo | Virology Journal BioMed Central Research Open Access N-methylisatin-beta-thiosemicarbazone derivative SCH 16 is an inhibitor of Japanese encephalitis virus infection in vitro and in vivo Liba Sebastian1 Anita Desai 1 Madhusudana N Shampur1 Yogeeswari Perumal2 D Sriram2 and Ravi Vasanthapuram1 Address Department of Neurovirology National Institute of Mental Health and Neuro Sciences Bangalore-560029 India and 2Department of Pharmacy Birla Institute of Technology and Sciences Pilani-333031 India Email Liba Sebastian - liba_sebastian@ Anita Desai - anitasdesai@ Madhusudana N Shampur - mshampur@ Yogeeswari Perumal - pyogee@ D Sriram - dsriram@ Ravi Vasanthapuram - virusravi@ Corresponding author Published 22 May 2008 Received 22 January 2008 Accepted 22 May 2008 Virology Journal 2008 5 64 doi l 743-422X-5-64 This article is available from http content 5 1 64 2008 Sebastian et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background During the early and mid part of 20th century several reports described the therapeutic effects of N-methylisatin-P-Thiosemicarbazone MIBT against pox viruses Maloney leukemia viruses and recently against HIV. However their ability to inhibit flavivirus replication has not been investigated. Hence the present study was designed to evaluate the antiviral activity of 14 MIBT derivatives against Flaviviruses that are prevalent in India such as Japanese Encephalitis Virus JEV Dengue-2 Den-2 and West Nile viruses WNV . Results Amongst the fourteen Mannich bases of MIBT derivatives tested one compound - SCH 16 was able to completely inhibit in vitro Japanese encephalitis virus JEV and West Nile
