Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Herpes simplex virus type-1(HSV-1) oncolytic and highly fusogenic mutants carrying the NV1020 genomic deletion effectively inhibit primary and metastatic tumors in mice | Virology Journal BioMed Central Open Access Herpes simplex virus type-l HSV-l oncolytic and highly fusogenic mutants carrying the NV1020 genomic deletion effectively inhibit primary and metastatic tumors in mice Anna Israyelyan1 2 Vladimir N Chouljenko1 2 Abolghasem Baghian1 2 Andrew T David1 2 Michael T Kearney2 and Konstantin G Kousoulas 1 2 Address division of Biotechnology and Molecular Medicine and Department of Pathobiological Sciences School of Veterinary Medicine Louisiana State University Baton Rouge LA 70803 USA and 2Department of Pathobiological Sciences School of Veterinary Medicine Louisiana State University Baton Rouge LA 70803 USA Email Anna Israyelyan - aisray1@ Vladimir N Chouljenko - vladimir@ Abolghasem Baghian - abaghian@ Andrew T David - adavid@ Michael T Kearney - mtk@ Konstantin G Kousoulas - vtgusk@ Corresponding author Published 2 June 2008 Received 10 April 2008 Virology Journal 2008 5 68 doi 186 1743-422X-5-68 Accepted 2 June 2008 This article is available from http content 5 1 68 2008 Israyelyan et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The NV1020 oncolytic herpes simplex virus type-1 has shown significant promise for the treatment of many different types of tumors in experimental animal models and human trials. Previously we described the construction and use of the NV1020-like virus OncSyn to treat human breast tumors implanted in nude mice. The syncytial mutation gKsyn1 Ala-to-Val at position 40 was introduced into the OncSyn viral genome cloned into a bacterial artificial chromosome using double-red mutagenesis in E. coli to produce the OncdSyn virus carrying syncytial
