Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: A predominance of R5-like HIV genotypes in vaginal secretions is associated with elevated plasma HIV-1 RNA levels and the absence of anti-retroviral therapy | Virology Journal BioMed Central Open Access Short report A predominance of R5-like HIV genotypes in vaginal secretions is associated with elevated plasma HIV-1 RNA levels and the absence of anti-retroviral therapy Tara C Randolph1 Patricia J Kissinger2 Rebecca A Clark1 Nedra Lacour1 and Angela M Amedee 1 Address Department of Microbiology Immunology and Parasitology Louisiana State University Health Sciences Center New Orleans LA USA and 2School of Public Health and Tropical Medicine Tulane University Health Sciences Center New Orleans LA USA Email Tara C Randolph - trand1@ Patricia J Kissinger - kissing@ Rebecca A Clark - rclark@ Nedra Lacour - nlacou@ Angela M Amedee - aamede@ Corresponding author Published 29 July 2008 Received 2 May 2008 Virology Journal 2008 5 87 doi 1743-422X-5-87 Accepted 29 July 2008 This article is available from http content 5 1 87 2008 Randolph et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract HIV expressed in genital secretions provides the inoculum from which transmitting variants are selected both in sexual transmission and mother-to-infant transmission during partuition. Characterization of HIV levels and genotypes found in vaginal secretions and the impact of antiretroviral therapy ART on this virus can provide valuable insight for the prevention of HIV transmission. Vaginal HIV was evaluated in a cohort of 43 women attending a New Orleans HIV outpatient clinic. Predominant vaginal genotypes were characterized as R5- or X4-like by heteroduplex tracking analyses of the envelope V3 region. Most women shed R5-like genotypes in vaginal secretions which was associated with elevated plasma HIV levels 10 .
