Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Experimental observations of rapid Maize streak virus evolution reveal a strand-specific nucleotide substitution bias | Virology Journal BioMed Central Open Access Experimental observations of rapid Maize streak virus evolution reveal a strand-specific nucleotide substitution bias Eric van der Walt1 Darren P Martin2 Arvind Varsani1 3 Jane E Polston4 and Edward P Rybicki 1 2 Address Department of Molecular and Cell Biology University of Cape Town Cape Town South Africa institute of Infectious Disease and Molecular Medicine University of Cape Town Cape Town South Africa 3Electron Microscope Unit University of Cape Town Cape Town South Africa and 4University of Florida Interdisciplinary Centre for Biotechnology Research Bradenton USA Email Eric van der Walt - Darren P Martin - Arvind Varsani - Jane E Polston - jep@ Edward P Rybicki - Corresponding author Published 24 September 2008 Received 17 June 2008 Accepted 24 September 2008 Virology Journal 2008 5 104 doi l743-422X-5-l04 This article is available from http content 5 l l04 2008 Walt et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Recent reports have indicated that single-stranded DNA ssDNA viruses in the taxonomic families Geminiviridae Parvoviridae and Anellovirus may be evolving at rates of l0-4 substitutions per site per year subs site year . These evolution rates are similar to those of RNA viruses and are surprisingly high given that ssDNA virus replication involves host DNA polymerases with fidelities approximately l0 000 times greater than those of error-prone viral RNA polymerases. Although high ssDNA virus evolution rates were first suggested in evolution experiments involving the geminivirus maize streak virus MSV the
